Disable Usb Drives in Registry Editor
This method works in all editions of running Windows 10, and
it disconnects only USB drives, without affecting the mouse, keyboard, and
printer connected via USB. Before editing the registry, it is recommended to
create a system restore point.
Open Windows registry editor: in the search bar or in the
menu to execute (run with the Win + R keys) enter the regedit command and press
the Enter key.
Go to HKEY_LOCAL_MACHINE \ SYSTEM \ CurrentControlSet \
Services \ USBSTOR. In the USBSTOR section, open the Start ⇨
parameter in the “Value”
field, set 4 and click “OK”.
Now, if you connect a USB flash drive to a computer, it will
not be displayed anywhere, and in Device Manager you will see an error
installing the driver for this device. If you want to re-enable USB drives in
the future — change the value of the “Start” parameter to 3 and click “OK”.